Article
Molecular and clinical analyses of PHF6 mutant myeloid neoplasia provide their pathogenesis and therapeutic targeting.
Nature communications - 28 Feb 2024
Kubota Yasuo, Gu Xiaorong, Terkawi Laila, Bodo Juraj, Przychodzen Bartlomiej P, Awada Hussein, Williams Nakisha, Gurnari Carmelo, Kawashima Naomi, Aly Mai, Durmaz Arda, Mori Minako, Ponvilawan Ben, Kewan Tariq, Bahaj Waled, Meggendorfer Manja, Jha Babal K, Visconte Valeria, Rogers Heesun J, Haferlach Torsten, Maciejewski Jaroslaw P
Abstract excerpt
PHF6 mutations (PHF6MT) are identified in various myeloid neoplasms (MN). However, little is known about the precise function and consequences of PHF6 in MN. Here we show three main findings in our comprehensive genomic and proteomic study. Firstly, we show a different pattern of genes correlating with PHF6MT in male and female cases. When analyzing male and female cases separately, in only male cases, RUNX1 and...
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