Article

Leukemia-mutated proteins PHF6 and PHIP form a chromatin complex that represses acute myeloid leukemia stemness

2024-12-03

Abstract excerpt

Myeloid leukemias are heterogeneous cancers with diverse mutations, sometimes in genes with unclear roles and unknown functional partners. PHF6 and PHIP are two poorly-understood chromatin-binding proteins recurrently mutated in acute myeloid leukemia (AML). PHF6 mutations are associated with poorer outcomes, while PHIP was recently identified as the most common selective mutation in Black patients in AML. Here,...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f49f2d99-0a8a-547d-a69d-e720a6acc741
DOI: 10.1101/2024.11.29.625909

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Leukemia-mutated proteins PHF6 and PHIP form a chromatin complex that represses acute myeloid leukemia stemnessDOI 10.1101/2024.11.29.625909Read

Leukemia mutated proteins PHF6 and PHIP form a chromatin complex that represses acute myeloid leukemia stemness.Semantic proximity Read

A new link in the leukemia genetic puzzle.Semantic proximity Read

PHF6 suppresses self-renewal of leukemic stem cells in AMLSemantic proximity Read

PHF6 Mutations in Hematologic MalignanciesSemantic proximity Read

PHF6 regulates phenotypic plasticity through chromatin organization within lineage-specific genes.Semantic proximity Read

Molecular and clinical analyses of PHF6 mutant myeloid neoplasia provide their pathogenesis and therapeutic targeting.Semantic proximity Read

Phf6 truncating mutation drives leukemogenesis via disrupted epigenetic regulation in mice.Semantic proximity Read

Phf6-null hematopoietic stem cells have enhanced self-renewal capacity and oncogenic potentialsSemantic proximity Read

Clinical Characteristics, Gene Mutation Profiles and Prognosis of Patients With Acute Myeloid Leukemia Carrying PHF6 Mutations.Semantic proximity Read

PHF6 mutations in adult acute myeloid leukemia.Semantic proximity Read

PHF6 mutations in myelodysplastic syndromes, chronic myelomonocytic leukemia and acute myeloid leukemiaSemantic proximity Read

A genome-scale in vivo loss-of-function screen identifies Phf6 as a lineage-specific regulator of leukemia cell growth.Semantic proximity Read