Article
Antibiotic dose and nutrient availability differentially drive the evolution of antibiotic resistance and persistence.
The ISME journal - 8 Jan 2024
Windels Etthel M, Cool Lloyd, Persy Eline, Swinnen Janne, Matthay Paul, Van den Bergh Bram, Wenseleers Tom, Michiels Jan
Abstract excerpt
Effective treatment of bacterial infections proves increasingly challenging due to the emergence of bacterial variants that endure antibiotic exposure. Antibiotic resistance and persistence have been identified as two major bacterial survival mechanisms, and several studies have shown a rapid and strong selection of resistance or persistence mutants under repeated drug treatment. Yet, little is known about the...
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