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Article

Multi-step vs. single-step resistance evolution under different drugs, pharmacokinetics, and treatment regimens.

eLife - 18 May 2021

Igler Claudia, Rolff Jens, Regoes Roland

Abstract excerpt

The success of antimicrobial treatment is threatened by the evolution of drug resistance. Population genetic models are an important tool in mitigating that threat. However, most such models consider resistance emergence via a single mutational step. Here, we assembled experimental evidence that drug resistance evolution follows two patterns: (i) a single mutation, which provides a large resistance benefit, or...

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Identifiers

PMID: 34001313
DOI: 10.7554/eLife.64116
PMCID: PMC8184216

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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