Article

Building reusable phage and antibiotic treatments via exploitation of bacteria-phage coevolutionary dynamics

2021-03-31

Abstract excerpt

People with chronic (long-lasting) infections face the problem that treatment options diminish in time as the pathogen evolves increasing resistance. To address this challenge, we exploit phage and bacterial co-evolution, producing dynamic selection pressures that can return the pathogen to a state of susceptibility to the initial (regulator-approved) therapy. We show that phage OMKO1 alone triggers Arms Race Dyna...

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Literature Corpus work: dd0b4284-3b56-5ccb-bd60-06ddbc357bc9
DOI: 10.1101/2021.03.31.437900

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