Article

Age-dependent heterogeneity in the antigenic effects of mutations to influenza hemagglutinin

2023-12-12

Abstract excerpt

<h4> ABSTRACT </h4> Human influenza virus evolves to escape neutralization by polyclonal antibodies. However, we have a limited understanding of how the antigenic effects of viral mutations vary across the human population, and how this heterogeneity affects virus evolution. Here we use deep mutational scanning to map how mutations to the hemagglutinin (HA) proteins of the A/Hong Kong/45/2019 (H3N2) and A/Perth/...

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Literature Corpus work: 0e495b6e-93df-5809-88fc-50668a48570c
DOI: 10.1101/2023.12.12.571235

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