Article

Deep mutational scanning of hemagglutinin helps predict evolutionary fates of human H3N2 influenza variants

2018-04-10

Abstract excerpt

Human influenza virus rapidly accumulates mutations in its major surface protein hemagglutinin (HA). The evolutionary success of influenza virus lineages depends on how these mutations affect HA’s functionality and antigenicity. Here we experimentally measure the effects on viral growth in cell culture of all single amino-acid mutations to the HA from a recent human H3N2 influenza virus strain. We show that mutati...

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Literature Corpus work: 016dfa1b-ac54-5a01-8e22-9ba9da3a5e25
DOI: 10.1101/298364

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