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Subtype- and antigenic site-specific differences in biophysical influences on evolution of influenza virus hemagglutinin

8 May 2012

Abstract excerpt

BACKGROUND: Influenza virus undergoes rapid evolution by both antigenic shift and antigenic drift. Antibodies, particularly those binding near the receptor-binding site of hemagglutinin (HA) or the neuraminidase (NA) active site, are thought to be the primary defense against influenza infection, and mutations in antibody binding sites can reduce or eliminate antibody binding. The binding of antibodies to their...

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PMID: 22569196
DOI: 10.1186/1743-422x-9-91

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