Article

High-throughput neutralization measurements correlate strongly with evolutionary success of human influenza strains

2025-03-12

Abstract excerpt

Human influenza viruses rapidly acquire mutations in their hemagglutinin (HA) protein that erode neutralization by antibodies from prior exposures. Here, we use a sequencing-based assay to measure neutralization titers for 78 recent H3N2 HA strains against a large set of children and adult sera, measuring ∼10,000 total titers. There is substantial person-to-person heterogeneity in the titers against different vira...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 9f633c33-5c40-519e-b1b8-386819300d38
DOI: 10.1101/2025.03.04.641544

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

High-throughput neutralization measurements correlate strongly with evolutionary success of human influenza strainsDOI 10.1101/2025.03.04.641544Read

Near real-time data on the human neutralizing antibody landscape to influenza virus as of early 2026 to inform vaccine-strain selectionSemantic proximity Read

High-throughput sequencing-based neutralization assay reveals how repeated vaccinations impact titers to recent human H1N1 influenza strainsSemantic proximity Read

High-throughput sequencing-based neutralization assay reveals how repeated vaccinations impact titers to recent human H1N1 influenza strainsSemantic proximity Read

Clade-defining mutations in human H1N1 hemagglutinin protein from 2021-2023 have opposing effects on in vitro fitness and antigenic driftSemantic proximity Read

Deep mutational scanning of H5 hemagglutinin to inform influenza virus surveillance.Semantic proximity Read

Isolation, identification, and whole genome sequencing analysis of influenza A virus clinical isolates from Shanghai, China, during 2022-2023.Semantic proximity Read

Using Interpretable Machine Learning to Massively Increase the Number of Antibody-Virus Interactions Across StudiesSemantic proximity Read

Intrahost HA polymorphisms and culture adaptation shape antigenic profiles of H3N2 influenza viruses.Semantic proximity Read

Deep mutational scanning of hemagglutinin helps predict evolutionary fates of human H3N2 influenza variantsSemantic proximity Read

Age-dependent heterogeneity in the antigenic effects of mutations to influenza hemagglutinin.Semantic proximity Read

Identification of a Key Hemagglutinin Mutation Mediating Antibody Escape in Influenza A(H1N1)pdm09 Viruses.Semantic proximity Read

A Panel of Human Monoclonal Antibodies for Tracking the Antigenic Evolution of Influenza H5N1 Clade 2.3.4.4bSemantic proximity Read