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Article

Deep mutational scanning of H5 hemagglutinin to inform influenza virus surveillance.

PLoS biology - 1 Nov 2024

Dadonaite Bernadeta, Ahn Jenny J, Ort Jordan T, Yu Jin, Furey Colleen, Dosey Annie, Hannon William W, Vincent Baker Amy L, Webby Richard J, King Neil P, Liu Yan, Hensley Scott E, Peacock Thomas P, Moncla Louise H, Bloom Jesse D

Abstract excerpt

H5 influenza is considered a potential pandemic threat. Recently, H5 viruses belonging to clade 2.3.4.4b have caused large outbreaks in avian and multiple nonhuman mammalian species. Previous studies have identified molecular phenotypes of the viral hemagglutinin (HA) protein that contribute to pandemic potential in humans, including cell entry, receptor preference, HA stability, and reduced neutralization by...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39531474
DOI: 10.1371/journal.pbio.3002916
PMCID: PMC11584116

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