Article

Natural variation in neuraminidase activity influences the evolutionary potential of the seasonal H1N1 lineage hemagglutinin

2024-03-18

Abstract excerpt

<h4>ABSTRACT</h4> The antigenic evolution of the influenza A virus hemagglutinin (HA) gene poses a major challenge for the development of vaccines capable of eliciting long-term protection. Prior efforts to understand the mechanisms that govern viral antigenic evolution mainly focus on HA in isolation, ignoring the fact that HA must act in concert with the viral neuraminidase (NA) during replication and spread. N...

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Literature Corpus work: 2499c61a-5753-5d09-ada3-b29766732fa4
DOI: 10.1101/2024.03.18.585603

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