Article
Age-dependent heterogeneity in the antigenic effects of mutations to influenza hemagglutinin.
Cell host & microbe - 14 Aug 2024
Welsh Frances C, Eguia Rachel T, Lee Juhye M, Haddox Hugh K, Galloway Jared, Van Vinh Chau Nguyen, Loes Andrea N, Huddleston John, Yu Timothy C, Quynh Le Mai, Nhat Nguyen T D, Thi Le Thanh Nguyen, Greninger Alexander L, Chu Helen Y, Englund Janet A, Bedford Trevor, Matsen Frederick A, Boni Maciej F, Bloom Jesse D
Abstract excerpt
Human influenza virus evolves to escape neutralization by polyclonal antibodies. However, we have a limited understanding of how the antigenic effects of viral mutations vary across the human population and how this heterogeneity affects virus evolution. Here, we use deep mutational scanning to map how mutations to the hemagglutinin (HA) proteins of two H3N2 strains, A/Hong Kong/45/2019 and A/Perth/16/2009,...
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