Article

Geometric constraints dominate the antigenic evolution of influenza H3N2 hemagglutinin

2015-01-22

Abstract excerpt

We have carried out a comprehensive analysis of the determinants of human influenza A H3 hemagglutinin evolution, considering three distinct predictors of evolutionary variation at individual sites: solvent accessibility (as a proxy for protein fold stability and/or conservation), experimental epitope sites (as a proxy for host immune bias), and proximity to the receptor-binding region (as a proxy for protein func...

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Literature Corpus work: 42965602-062d-5c78-add6-f2574ac69f9a
DOI: 10.1101/014183

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