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Article

Identification of a Key Hemagglutinin Mutation Mediating Antibody Escape in Influenza A(H1N1)pdm09 Viruses.

Viruses - 12 Mar 2026

Song Weili, Wang Chuan, Xie Wenping, Li Yiqing, Chen Kaiyun, Song Wenjun, Jiang Taijiao

Abstract excerpt

BACKGROUND: The H1N1 influenza A virus evades host immunity through continuous antigenic drift, posing a significant challenge to broad-spectrum neutralizing antibody therapies. This study aims to systematically evaluate the neutralizing capacity of the broad-spectrum antibody C12H5 against H1N1 strains from different eras and identify key immune escape mutation sites. METHODS: Three representative H1N1 virus...

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Share to Antibodies, Neutralizing
Share to Antibodies, Viral

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hemagglutinin Glycoproteins, Influenza Virus

Share to Immune Evasion

Share to Influenza A Virus, H1N1 Subtype

Share to Influenza, Human

Share to Madin Darby Canine Kidney Cells

Share to Neutralization Tests

Source

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Identifiers

PMID: 41902257
DOI: 10.3390/v18030349
PMCID: PMC13030865

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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