Article

Performance of African-ancestry-specific polygenic hazard score varies according to local ancestry in 8q24

2021-01-26

Abstract excerpt

We previously developed an African-ancestry-specific polygenic hazard score (PHS46+African) that substantially improved prostate cancer risk stratification in men with African ancestry. The model consists of 46 SNPs identified in Europeans and 3 SNPs from 8q24 shown to improve model performance in Africans. Herein, we used principal component (PC) analysis to uncover subpopulations of men with African ancestry for...

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Literature Corpus work: 0e1551d4-144f-53ae-b08a-80ceddf649e0
DOI: 10.1101/2021.01.20.21249985

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