Article
African-specific improvement of a polygenic hazard score for age at diagnosis of prostate cancer.
International journal of cancer - 1 Jan 2021
Karunamuni Roshan A, Huynh-Le Minh-Phuong, Fan Chun C, Thompson Wesley, Eeles Rosalind A, Kote-Jarai Zsofia, Muir Kenneth, Lophatananon Artitaya, Tangen Catherine M, Goodman Phyllis J, Thompson Ian M, Blot William J, Zheng Wei, Kibel Adam S, Drake Bettina F, Cussenot Olivier, Cancel-Tassin Géraldine, Menegaux Florence, Truong Thérèse, Park Jong Y, Lin Hui-Yi, Bensen Jeannette T, Fontham Elizabeth T H, Mohler James L, Taylor Jack A, Multigner Luc, Blanchet Pascal, Brureau Laurent, Romana Marc, Leach Robin J, John Esther M, Fowke Jay, Bush William S, Aldrich Melinda, Crawford Dana C, Srivastava Shiv, Cullen Jennifer C, Petrovics Gyorgy, Parent Marie-Élise, Hu Jennifer J, Sanderson Maureen, Mills Ian G, Andreassen Ole A, Dale Anders M, Seibert Tyler M
Abstract excerpt
Polygenic hazard score (PHS) models are associated with age at diagnosis of prostate cancer. Our model developed in Europeans (PHS46) showed reduced performance in men with African genetic ancestry. We used a cross-validated search to identify single nucleotide polymorphisms (SNPs) that might improve performance in this population. Anonymized genotypic data were obtained from the PRACTICAL consortium for 6253 men...
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