Article
Performance of African-ancestry-specific polygenic hazard score varies according to local ancestry in 8q24.
Prostate cancer and prostatic diseases - 1 Feb 2022
Karunamuni Roshan A, Huynh-Le Minh-Phuong, Fan Chun C, Thompson Wesley, Lui Asona, Martinez Maria Elena, Rose Brent S, Mahal Brandon, Eeles Rosalind A, Kote-Jarai Zsofia, Muir Kenneth, Lophatananon Artitaya, Tangen Catherine M, Goodman Phyllis J, Thompson Ian M, Blot William J, Zheng Wei, Kibel Adam S, Drake Bettina F, Cussenot Olivier, Cancel-Tassin Géraldine, Menegaux Florence, Truong Thérèse, Park Jong Y, Lin Hui-Yi, Taylor Jack A, Bensen Jeannette T, Mohler James L, Fontham Elizabeth T H, Multigner Luc, Blanchet Pascal, Brureau Laurent, Romana Marc, Leach Robin J, John Esther M, Fowke Jay H, Bush William S, Aldrich Melinda C, Crawford Dana C, Cullen Jennifer, Petrovics Gyorgy, Parent Marie-Élise, Hu Jennifer J, Sanderson Maureen, Mills Ian G, Andreassen Ole A, Dale Anders M, Seibert Tyler M
Abstract excerpt
BACKGROUND: We previously developed an African-ancestry-specific polygenic hazard score (PHS46+African) that substantially improved prostate cancer risk stratification in men with African ancestry. The model consists of 46 SNPs identified in Europeans and 3 SNPs from 8q24 shown to improve model performance in Africans. Herein, we used principal component (PC) analysis to uncover subpopulations of men with African...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.