Article
Testing the generalizability of ancestry-specific polygenic risk scores to predict prostate cancer in sub-Saharan Africa.
Genome biology - 13 Sept 2022
Kim Michelle S, Naidoo Daphne, Hazra Ujani, Quiver Melanie H, Chen Wenlong C, Simonti Corinne N, Kachambwa Paidamoyo, Harlemon Maxine, Agalliu Ilir, Baichoo Shakuntala, Fernandez Pedro, Hsing Ann W, Jalloh Mohamed, Gueye Serigne M, Niang Lamine, Diop Halimatou, Ndoye Medina, Snyper Nana Yaa, Adusei Ben, Mensah James E, Abrahams Afua O D, Biritwum Richard, Adjei Andrew A, Adebiyi Akindele O, Shittu Olayiwola, Ogunbiyi Olufemi, Adebayo Sikiru, Aisuodionoe-Shadrach Oseremen I, Nwegbu Maxwell M, Ajibola Hafees O, Oluwole Olabode P, Jamda Mustapha A, Singh Elvira, Pentz Audrey, Joffe Maureen, Darst Burcu F, Conti David V, Haiman Christopher A, Spies Petrus V, van der Merwe André, Rohan Thomas E, Jacobson Judith, Neugut Alfred I, McBride Jo, Andrews Caroline, Petersen Lindsay N, Rebbeck Timothy R, Lachance Joseph
Abstract excerpt
BACKGROUND: Genome-wide association studies do not always replicate well across populations, limiting the generalizability of polygenic risk scores (PRS). Despite higher incidence and mortality rates of prostate cancer in men of African descent, much of what is known about cancer genetics comes from populations of European descent. To understand how well genetic predictions perform in different populations, we...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.