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Article

PRState: Incorporating genetic ancestry in prostate cancer risk scores for men of African ancestry.

BMC cancer - 9 Dec 2022

Pagadala Meghana S, Linscott Joshua A, Talwar James V, Seibert Tyler M, Rose Brent, Lynch Julie, Panizzon Matthew, Hauger Richard, Hansen Moritz H, Sammon Jesse D, Hayn Matthew H, Kader Karim, Carter Hannah, Ryan Stephen T

Abstract excerpt

BACKGROUND: Prostate cancer (PrCa) is one of the most genetically driven solid cancers with heritability estimates as high as 57%. Men of African ancestry are at an increased risk of PrCa; however, current polygenic risk score (PRS) models are based on European ancestry groups and may not be broadly applicable. The objective of this study was to construct an African ancestry-specific PrCa PRS (PRState) and...

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Identifiers

PMID: 36494783
DOI: 10.1186/s12885-022-10258-3
PMCID: PMC9733391

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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