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Benchmarking multi-ancestry prostate cancer polygenic risk scores in a real-world cohort.

PLoS computational biology - 1 Apr 2024

Shah Yajas, Kulm Scott, Nauseef Jones T, Chen Zhengming, Elemento Olivier, Kensler Kevin H, Sharaf Ravi N

Abstract excerpt

Prostate cancer is a heritable disease with ancestry-biased incidence and mortality. Polygenic risk scores (PRSs) offer promising advancements in predicting disease risk, including prostate cancer. While their accuracy continues to improve, research aimed at enhancing their effectiveness within African and Asian populations remains key for equitable use. Recent algorithmic developments for PRS derivation have...

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Identifiers

PMID: 38598551
DOI: 10.1371/journal.pcbi.1011990
PMCID: PMC11034641

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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