Article
Prostate cancer risk stratification improvement across multiple ancestries with new polygenic hazard score.
Prostate cancer and prostatic diseases - 1 Apr 2022
Huynh-Le Minh-Phuong, Karunamuni Roshan, Fan Chun Chieh, Asona Lui, Thompson Wesley K, Martinez Maria Elena, Eeles Rosalind A, Kote-Jarai Zsofia, Muir Kenneth R, Lophatananon Artitaya, Schleutker Johanna, Pashayan Nora, Batra Jyotsna, Grönberg Henrik, Neal David E, Nordestgaard Børge G, Tangen Catherine M, MacInnis Robert J, Wolk Alicja, Albanes Demetrius, Haiman Christopher A, Travis Ruth C, Blot William J, Stanford Janet L, Mucci Lorelei A, West Catharine M L, Nielsen Sune F, Kibel Adam S, Cussenot Olivier, Berndt Sonja I, Koutros Stella, Sørensen Karina Dalsgaard, Cybulski Cezary, Grindedal Eli Marie, Menegaux Florence, Park Jong Y, Ingles Sue A, Maier Christiane, Hamilton Robert J, Rosenstein Barry S, Lu Yong-Jie, Watya Stephen, Vega Ana, Kogevinas Manolis, Wiklund Fredrik, Penney Kathryn L, Huff Chad D, Teixeira Manuel R, Multigner Luc, Leach Robin J, Brenner Hermann, John Esther M, Kaneva Radka, Logothetis Christopher J, Neuhausen Susan L, De Ruyck Kim, Ost Piet, Razack Azad, Newcomb Lisa F, Fowke Jay H, Gamulin Marija, Abraham Aswin, Claessens Frank, Castelao Jose Esteban, Townsend Paul A, Crawford Dana C, Petrovics Gyorgy, van Schaik Ron H N, Parent Marie-Élise, Hu Jennifer J, Zheng Wei, Mills Ian G, Andreassen Ole A, Dale Anders M, Seibert Tyler M
Abstract excerpt
BACKGROUND: Prostate cancer risk stratification using single-nucleotide polymorphisms (SNPs) demonstrates considerable promise in men of European, Asian, and African genetic ancestries, but there is still need for increased accuracy. We evaluated whether including additional SNPs in a prostate cancer polygenic hazard score (PHS) would improve associations with clinically significant prostate cancer in...
Read the complete abstract on PubMed