Article
Additional SNPs improve risk stratification of a polygenic hazard score for prostate cancer.
Prostate cancer and prostatic diseases - 1 Jun 2021
Karunamuni Roshan A, Huynh-Le Minh-Phuong, Fan Chun C, Thompson Wesley, Eeles Rosalind A, Kote-Jarai Zsofia, Muir Kenneth, Lophatananon Artitaya, Schleutker Johanna, Pashayan Nora, Batra Jyotsna, Grönberg Henrik, Walsh Eleanor I, Turner Emma L, Lane Athene, Martin Richard M, Neal David E, Donovan Jenny L, Hamdy Freddie C, Nordestgaard Børge G, Tangen Catherine M, MacInnis Robert J, Wolk Alicja, Albanes Demetrius, Haiman Christopher A, Travis Ruth C, Stanford Janet L, Mucci Lorelei A, West Catharine M L, Nielsen Sune F, Kibel Adam S, Wiklund Fredrik, Cussenot Olivier, Berndt Sonja I, Koutros Stella, Sørensen Karina Dalsgaard, Cybulski Cezary, Grindedal Eli Marie, Park Jong Y, Ingles Sue A, Maier Christiane, Hamilton Robert J, Rosenstein Barry S, Vega Ana, Kogevinas Manolis, Penney Kathryn L, Teixeira Manuel R, Brenner Hermann, John Esther M, Kaneva Radka, Logothetis Christopher J, Neuhausen Susan L, Razack Azad, Newcomb Lisa F, Gamulin Marija, Usmani Nawaid, Claessens Frank, Gago-Dominguez Manuela, Townsend Paul A, Roobol Monique J, Zheng Wei, Mills Ian G, Andreassen Ole A, Dale Anders M, Seibert Tyler M
Abstract excerpt
BACKGROUND: Polygenic hazard scores (PHS) can identify individuals with increased risk of prostate cancer. We estimated the benefit of additional SNPs on performance of a previously validated PHS (PHS46). MATERIALS AND METHOD: 180 SNPs, shown to be previously associated with prostate cancer, were used to develop a PHS model in men with European ancestry. A machine-learning approach, LASSO-regularized Cox...
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