Article
Evaluating approaches for constructing polygenic risk scores for prostate cancer in men of African and European ancestry.
American journal of human genetics - 6 Jul 2023
Darst Burcu F, Shen Jiayi, Madduri Ravi K, Rodriguez Alexis A, Xiao Yukai, Sheng Xin, Saunders Edward J, Dadaev Tokhir, Brook Mark N, Hoffmann Thomas J, Muir Kenneth, Wan Peggy, Le Marchand Loic, Wilkens Lynne, Wang Ying, Schleutker Johanna, MacInnis Robert J, Cybulski Cezary, Neal David E, Nordestgaard Børge G, Nielsen Sune F, Batra Jyotsna, Clements Judith A, Cancer BioResource Australian Prostate, Grönberg Henrik, Pashayan Nora, Travis Ruth C, Park Jong Y, Albanes Demetrius, Weinstein Stephanie, Mucci Lorelei A, Hunter David J, Penney Kathryn L, Tangen Catherine M, Hamilton Robert J, Parent Marie-Élise, Stanford Janet L, Koutros Stella, Wolk Alicja, Sørensen Karina D, Blot William J, Yeboah Edward D, Mensah James E, Lu Yong-Jie, Schaid Daniel J, Thibodeau Stephen N, West Catharine M, Maier Christiane, Kibel Adam S, Cancel-Tassin Géraldine, Menegaux Florence, John Esther M, Grindedal Eli Marie, Khaw Kay-Tee, Ingles Sue A, Vega Ana, Rosenstein Barry S, Teixeira Manuel R, Kogevinas Manolis, Cannon-Albright Lisa, Huff Chad, Multigner Luc, Kaneva Radka, Leach Robin J, Brenner Hermann, Hsing Ann W, Kittles Rick A, Murphy Adam B, Logothetis Christopher J, Neuhausen Susan L, Isaacs William B, Nemesure Barbara, Hennis Anselm J, Carpten John, Pandha Hardev, De Ruyck Kim, Xu Jianfeng, Razack Azad, Teo Soo-Hwang, Newcomb Lisa F, Fowke Jay H, Neslund-Dudas Christine, Rybicki Benjamin A, Gamulin Marija, Usmani Nawaid, Claessens Frank, Gago-Dominguez Manuela, Castelao Jose Esteban, Townsend Paul A, Crawford Dana C, Petrovics Gyorgy, Casey Graham, Roobol Monique J, Hu Jennifer F, Berndt Sonja I, Van Den Eeden Stephen K, Easton Douglas F, Chanock Stephen J, Cook Michael B, Wiklund Fredrik, Witte John S, Eeles Rosalind A, Kote-Jarai Zsofia, Watya Stephen, Gaziano John M, Justice Amy C, Conti David V, Haiman Christopher A
Abstract excerpt
Genome-wide polygenic risk scores (GW-PRSs) have been reported to have better predictive ability than PRSs based on genome-wide significance thresholds across numerous traits. We compared the predictive ability of several GW-PRS approaches to a recently developed PRS of 269 established prostate cancer-risk variants from multi-ancestry GWASs and fine-mapping studies (PRS269). GW-PRS models were trained with a...