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Article

Reduction of insulin/IGF-1 receptor rejuvenates immunity via positive feedback circuit

2019-10-07

Abstract excerpt

<h4>Summary</h4> Immunosenescence is considered an inevitable decline in immune function during aging. Here we show that genetic inhibition of the DAF-2/insulin/IGF-1 receptor drastically delays immunosenescence and rejuvenates immunity in C. elegans . We find that p38 mitogen-activated protein kinase 1 (PMK-1), a key determinant of immunosenescence, is dispensable for this rejuvenated immunity. Instead, we demo...

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Literature Corpus work
0dbf9dda-abf4-5a02-ae74-23acdb64f0a0
DOI
10.1101/795781
Open publication

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Reduction of insulin/IGF-1 receptor rejuvenates immunity via positive feedback circuitDOI 10.1101/795781
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