Article

Germline activity of the heat shock factor HSF-1 programs the insulin-receptor <i>daf-2</i> in <i>C. elegans</i>

2021-02-22

Abstract excerpt

The mechanisms by which maternal stress alters offspring phenotypes remain poorly understood. Here we report that the heat shock transcription factor HSF-1, activated in the C. elegans maternal germline upon stress, epigenetically programs the insulin-like receptor daf-2 by increasing repressive H3K9me2 levels throughout the daf-2 gene. This increase occurs by the recruitment of the C. elegans SETDB1 homolog M...

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Literature Corpus work: 099e11a0-af1e-5ced-b3da-b29035ecf378
DOI: 10.1101/2021.02.22.432344

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