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Article

JNK extends life span and limits growth by antagonizing cellular and organism-wide responses to insulin signaling.

Cell - 8 Apr 2005

Wang Meng C, Bohmann Dirk, Jasper Heinrich

Abstract excerpt

Aging of a eukaryotic organism is affected by its nutrition state and by its ability to prevent or repair oxidative damage. Consequently, signal transduction systems that control metabolism and oxidative stress responses influence life span. When nutrients are abundant, the insulin/IGF signaling (IIS) pathway promotes growth and energy storage but shortens life span. The transcription factor Foxo, which is...

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PMID: 15820683
DOI: 10.1016/j.cell.2005.02.030

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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