Transcriptome Analysis of Insulin Signaling-Associated Transcription Factors in C. elegans Reveal Their Genome-Wide Target Genes Specificity and Complexity.

doi:10.3390/ijms222212462

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Transcriptome Analysis of Insulin Signaling-Associated Transcription Factors in C. elegans Reveal Their Genome-Wide Target Genes Specificity and Complexity.

International journal of molecular sciences - 18 Nov 2021

Kaushik Neha, Rastogi Soumya, Verma Sonia, Pandey Deepak, Halder Ashutosh, Mukhopadhyay Arnab, Kumar Neeraj

Abstract excerpt

Insulin/IGF-1-like signaling (IIS) plays a crucial, conserved role in development, growth, reproduction, stress tolerance, and longevity. In Caenorhabditis elegans, the enhanced longevity under reduced insulin signaling (rIIS) is primarily regulated by the transcription factors (TFs) DAF-16/FOXO, SKN-1/Nrf-1, and HSF1/HSF-1. The specific and coordinated regulation of gene expression by these TFs under rIIS has...

Topics

Animals
Caenorhabditis elegans
Caenorhabditis elegans Proteins
DNA-Binding Proteins
Forkhead Transcription Factors
Gene Expression Profiling
Gene Expression Regulation, Developmental
Gene Ontology
Gene Regulatory Networks

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genome, Helminth

Insulin

Longevity

Molecular Sequence Annotation

Phenotype

Signal Transduction

Transcription Factors

Transcriptome

Source

Open in PubMed Open full text

Identifiers

PMID: 34830338
DOI: 10.3390/ijms222212462
PMCID: PMC8618238

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