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Article

Transcriptome Analysis of Insulin Signaling-Associated Transcription Factors in C. elegans Reveal Their Genome-Wide Target Genes Specificity and Complexity.

International journal of molecular sciences - 18 Nov 2021

Kaushik Neha, Rastogi Soumya, Verma Sonia, Pandey Deepak, Halder Ashutosh, Mukhopadhyay Arnab, Kumar Neeraj

Abstract excerpt

Insulin/IGF-1-like signaling (IIS) plays a crucial, conserved role in development, growth, reproduction, stress tolerance, and longevity. In Caenorhabditis elegans, the enhanced longevity under reduced insulin signaling (rIIS) is primarily regulated by the transcription factors (TFs) DAF-16/FOXO, SKN-1/Nrf-1, and HSF1/HSF-1. The specific and coordinated regulation of gene expression by these TFs under rIIS has...

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PMID: 34830338
DOI: 10.3390/ijms222212462
PMCID: PMC8618238

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Source receipt: pubmed, retrieved 7 Sept 2026.

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