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Article

INS-17 acts as a nutrient deprivation signal to mediate adult IIS-regulated associative behaviors in C. elegans.

PLoS genetics - 1 Apr 2026

Leptich Emily J, Vijayakumar Priyadharshini, Pietryk Edward W, Williams Meredith I, Rajupalem Rachana, Arey Rachel N

Abstract excerpt

Insulin/Insulin-like growth factor 1 (IGF-1) signaling (IIS) is a pleiotropic signaling pathway that functions across tissues to coordinate phenotypic changes in response to nutrient status. Thus, the ubiquity of the IIS pathway hinders efforts to elucidate the mechanisms driving specific IIS-related phenotypes. Previous research in the nematode worm C. elegans has demonstrated that loss of function of the IIS...

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PMID: 42048395
DOI: 10.1371/journal.pgen.1012130
PMCID: PMC13143180

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INS

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