Article

Combining genetics with real-world patient data enables ancestry-specific target identification and drug discovery in Alzheimer’s disease

2025-01-15

Abstract excerpt

<title>Abstract</title> <p>Although high-throughput DNA/RNA sequencing technologies have generated massive genetic and genomic data in human disease, these findings have not been translated into new patient treatments. To address this problem, we utilized Mendelian randomization (MR) and large patient-level genetic and functional genomic data to evaluate druggable targets using Alzheimer’s disease (AD) as a proto...

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Literature Corpus work: 0dbb6095-9ae6-511a-9324-e998d301d174
DOI: 10.21203/rs.3.rs-5716817/v1

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