Article

Cross-tissue omics-guided drug repurposing triangulates novel targetable mechanisms for Alzheimer’s disease and candidate genetic biomarkers for treatment stratification

2025-08-05

Abstract excerpt

<title>Abstract</title> <p>White matter hyperintensities (WMH) are covert magnetic resonance imaging (MRI) - markers of microvascular dysfunction and are primary vascular contributors to dementia, emphasizing its importance in prevention strategies. Here, we integrate gene expression and protein levels measured across plasma, cerebrospinal fluid (CSF), brain and multiple other tissues from population-based and bi...

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Literature Corpus work: 6644a5c2-7450-518e-ad4f-c30aa22cdd8c
DOI: 10.21203/rs.3.rs-7279662/v1

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