Article
Identifying drug targets for neurological and psychiatric disease via genetics and the brain transcriptome.
PLoS genetics - 1 Jan 2021
Baird Denis A, Liu Jimmy Z, Zheng Jie, Sieberts Solveig K, Perumal Thanneer, Elsworth Benjamin, Richardson Tom G, Chen Chia-Yen, Carrasquillo Minerva M, Allen Mariet, Reddy Joseph S, De Jager Philip L, Ertekin-Taner Nilufer, Mangravite Lara M, Logsdon Ben, Estrada Karol, Haycock Philip C, Hemani Gibran, Runz Heiko, Smith George Davey, Gaunt Tom R
Abstract excerpt
Discovering drugs that efficiently treat brain diseases has been challenging. Genetic variants that modulate the expression of potential drug targets can be utilized to assess the efficacy of therapeutic interventions. We therefore employed Mendelian Randomization (MR) on gene expression measured in brain tissue to identify drug targets involved in neurological and psychiatric diseases. We conducted a two-sample...
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