Article
Combining xQTL and genome-wide association studies from diverse populations improves druggable gene discovery.
Nature communications - 14 Feb 2026
Lorincz-Comi Noah, Song Wenqiang, Chen Xin, Paz Isabela Rivera, Hou Yuan, Zhou Yadi, Xu Jielin, Martin William, Barnard John, Pieper Andrew A, Haines Jonathan L, Chung Mina K, Cheng Feixiong
Abstract excerpt
Repurposing existing medicines to target disease-associated genes represents a promising strategy for developing effective treatments for complex diseases. However, progress has been hindered by a lack of viable candidate drug targets identified through genome-wide association studies. Gene-based association tests provide a more powerful alternative to traditional SNP-based methods, yet current approaches often...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.