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Article

Crosstalk among Alternative Polyadenylation, Genetic Variants and Ubiquitin Modification Contribute to Lung Adenocarcinoma Risk.

International journal of molecular sciences - 24 Jul 2024

Wu Yutong, Yuan Yanqiong, Xu Huiwen, Zhang Wendi, Ning Anhui, Li Siqi, Chen Qiong, Tao Xiaobo, Pan Gongbu, Tian Tian, Zhang Lei, Chu Minjie, Cui Jiahua

Abstract excerpt

Ubiquitin modification and alternative polyadenylation play crucial roles in the onset and progression of cancer. Hence, this study aims to comprehensively and deeply understand gene regulation and associated biological processes in lung adenocarcinoma (LUAD) by integrating both mechanisms. Alternative polyadenylation (APA)-related E3 ubiquitin ligases in LUAD were identified through multiple databases, and the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39125654
DOI: 10.3390/ijms25158084
PMCID: PMC11311407

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