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Article

Evaluating the causal effect of circulating proteome on the risk of inflammatory bowel disease-related traits using Mendelian randomization.

Frontiers in immunology - 1 Jan 2024

Li Beining, Hu Ping, Liang Hongyan, Zhao Xingliang, Zhang Aiting, Xu Yingchong, Zhang Bin, Zhang Jie

Abstract excerpt

Objective: This study sought to identify circulating proteins causally linked to Inflammatory Bowel Disease (IBD) traits through a Mendelian Randomization (MR) analytical framework. Methods: Using a large-scale, two-sample MR approach, we estimated the genetic links of numerous plasma proteins with IBD and its subtypes, leveraging information from the Inflammatory Bowel Disease Genetics Consortium. To assess the...

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Blood Proteins
Genetic Predisposition to Disease
Genome-Wide Association Study
Inflammatory Bowel Diseases
Mendelian Randomization Analysis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymorphism, Single Nucleotide

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Identifiers

PMID: 39144148
DOI: 10.3389/fimmu.2024.1434369
PMCID: PMC11321985

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