Article

Phenome-wide Mendelian randomization identifying circulating proteins for cardiovascular traits in populations of African ancestry

2025-06-11

Abstract excerpt

<h4>Background</h4> Circulating proteins represent robust drug targets with therapeutic potential. Many discoveries have focused on European-ancestry populations, disregarding minuscule yet substantial proteomic differences that may contribute to disease and/or alter drug generalizability in other ancestry groups. <h4>Methods</h4> Using two-sample Mendelian randomization and colocalization, we analyzed the effects...

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Literature Corpus work: 59b66ab1-29e2-5a18-8a53-7584ccc51e38
DOI: 10.1101/2025.06.10.25329388

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