Back to search

Article

Assessing the Causal Impact of the Circulating Proteome on Susceptibility to Gastrointestinal Cancer-Associated Characteristics

2025-02-10

Abstract excerpt

<title>Abstract</title> <p><bold>Objectives</bold>This research endeavors to pinpoint circulating proteins that exhibit a causal relationship with traits related to gastrointestinal cancer through a Mendelian randomization (MR) analytical framework. Dysfunctionof the human plasma proteome is frequently observed in a plethora of diseases, including gastrointestinal cancers. Owing to their pivotal role, circulating...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
1e7322ef-4ed7-561a-a9bc-f96116870fc6
DOI
10.21203/rs.3.rs-5886780/v1
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Assessing the Causal Impact of the Circulating Proteome on Susceptibility to Gastrointestinal Cancer-Associated CharacteristicsDOI 10.21203/rs.3.rs-5886780/v1
Proteome-wide analysis reveals potential therapeutic targets for Colorectal cancer: a two-sample mendelian randomization study.Semantic proximity
Identification of novel protein biomarkers and drug targets for colorectal cancer by integrating human plasma proteome with genomeSemantic proximity
Evaluating the causal effect of circulating proteome on the risk of inflammatory bowel disease-related traits using Mendelian randomization.Semantic proximity
Associations of plasma protein levels with risk of colorectal cancer: a proteome-wide Mendelian randomization studySemantic proximity
Identification of novel protein biomarkers and drug targets for colorectal cancer by integrating human plasma proteome with genomeSemantic proximity
Employing plasma proteins in proteomic Mendelian randomization analysis to identify therapeutic targets for duodenal ulcer.Semantic proximity
Exploring the cross-cancer effect of circulating proteins and discovering potential intervention targets for 13 site-specific cancers.Semantic proximity
Causal roles and clinical utility of cardiovascular proteins in colorectal cancer risk: a multi-modal study integrating mendelian randomization, expression profiling, and survival analysis.Semantic proximity
Multi-ancestry proteome-phenome-wide Mendelian randomization offers a comprehensive protein-disease atlas and potential therapeutic targetsSemantic proximity
Genetic insights into blood protein correlations with colorectal cancer: a Mendelian randomization studySemantic proximity
Systematic Mendelian randomization using the human plasma proteome to identify therapeutic targets for lung adenocarcinomaSemantic proximity
Integrating plasma protein-centric multi-omics to identify potential therapeutic targets for pancreatic cancer.Semantic proximity
Select a neighboring publication to make it the new centre.