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Article

Phenome-Wide Mendelian Randomization Identifying Circulating Proteins for Cardiovascular Traits in Populations of African Ancestry.

Circulation. Genomic and precision medicine - 1 Apr 2026

Selber-Hnatiw Susannah, Trajanoska Katerina, Pelletier Justin, Su Chen-Yang, McClelland Peyton, Taliun Daniel, Yoshiji Satoshi, Mooser Vincent, Bhérer Claude, Zhou Sirui

Abstract excerpt

BACKGROUND: Circulating proteins represent robust drug targets with therapeutic potential. Many discoveries have focused on European-ancestry populations, disregarding minuscule yet substantial proteomic differences that may contribute to disease and alter drug generalizability in other ancestry groups. METHODS: Using 2-sample Mendelian randomization and colocalization, we analyzed the effects of 1562 circulating...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41657222
DOI: 10.1161/CIRCGEN.125.005159

Genes

APOC1
CD36
FOLH1
GSTA1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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