Back to search

Article

Proteome-wide Mendelian randomization identifies candidate causal proteins for cardiovascular diseases

2023-10-17

Abstract excerpt

<h4>Background</h4> Cardiovascular diseases (CVD) remain the leading cause of death worldwide, while a lack of clarity on underlying mechanisms has hindered development of novel therapies. Integration of human genetics and proteomics across different ancestries can provide novel, affordable, and systematic approach for target identification and prioritization. <h4>Methods</h4> Mendelian randomization approach was...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
d4c59907-f487-51b2-81c7-db4e8e8bfe02
DOI
10.1101/2023.10.16.23297103
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Proteome-wide Mendelian randomization identifies candidate causal proteins for cardiovascular diseasesDOI 10.1101/2023.10.16.23297103
Therapeutic protein targets for cardiometabolic diseases: Mendelian randomization integrating plasma proteomes with genome-wide association dataSemantic proximity
Cross-population proteome-wide mendelian randomization study identifies likely causal proteins for cardiovascular diseases.Semantic proximity
Shared proteomic landscape between arteriosclerosis and cardiovascular endpoints: a Mendelian randomization and observational study integrating AlphaFold3 for structural predictionSemantic proximity
Exploring Potential Drug Targets in Multiple Cardiovascular Diseases: A Study Based on Proteome‐Wide Mendelian Randomization and Colocalization AnalysisSemantic proximity
Genetic associations of circulating plasma proteins with cardiometabolic diseases.Semantic proximity
Plasma proteins and onset of atherosclerosis: Integrating human plasma proteogenomics, transcriptomics and in vivo evidenceSemantic proximity
Causal Effect of Multi-cohort Circulating Proteome on the Risk of Aortic Aneurysm: A Mendelian Randomization StudySemantic proximity
Comprehensive mendelian randomization analysis of plasma proteomics to identify new therapeutic targets for the treatment of coronary heart disease and myocardial infarctionSemantic proximity
Blood plasma proteome-wide association study implicates novel proteins in the pathogenesis of multiple cardiovascular diseases.Semantic proximity
Causal Effect of Multicohort Circulating Proteome on the Risk of Aortic Aneurysm: A Mendelian Randomization Study.Semantic proximity
Phenome-wide Mendelian randomization identifying circulating proteins for cardiovascular traits in populations of African ancestrySemantic proximity
Genomic evaluation of circulating proteins for drug target characterisation and precision medicineSemantic proximity
Select a neighboring publication to make it the new centre.