Article

Therapeutic protein targets for cardiometabolic diseases: Mendelian randomization integrating plasma proteomes with genome-wide association data

2024-05-30

Abstract excerpt

<title>Abstract</title> <p>Cardiovascular disease (CVD) is the leading cause of death worldwide, and its risk is inseparable from metabolic abnormalities. Through summary-data-based Mendelian randomization and colocalization analysis, we investigated the causal relationships between plasma proteins, 6 cardiovascular diseases, and 19 metabolic phenotypes. We identified 49 proteins genetically associated with CVDs,...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 2e5074f1-5ca3-5238-ada7-41227aa27552
DOI: 10.21203/rs.3.rs-4431488/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Therapeutic protein targets for cardiometabolic diseases: Mendelian randomization integrating plasma proteomes with genome-wide association dataDOI 10.21203/rs.3.rs-4431488/v1Read

Genetic associations of circulating plasma proteins with cardiometabolic diseases.Semantic proximity Read

Proteome-wide Mendelian randomization identifies candidate causal proteins for cardiovascular diseasesSemantic proximity Read

Exploring Potential Drug Targets in Multiple Cardiovascular Diseases: A Study Based on Proteome‐Wide Mendelian Randomization and Colocalization AnalysisSemantic proximity Read

Comprehensive mendelian randomization analysis of plasma proteomics to identify new therapeutic targets for the treatment of coronary heart disease and myocardial infarctionSemantic proximity Read

Plasma proteins and onset of atherosclerosis: Integrating human plasma proteogenomics, transcriptomics and in vivo evidenceSemantic proximity Read

Cross-population proteome-wide mendelian randomization study identifies likely causal proteins for cardiovascular diseases.Semantic proximity Read

Potential Therapeutic Drug Targets for Hypertension Identified Using Proteomics and Mendelian Randomization.Semantic proximity Read

Measured and genetically predicted protein levels and cardiovascular diseases in UK Biobank and China Kadoorie Biobank.Semantic proximity Read

Proteomic analysis of 92 circulating proteins and their effects in cardiometabolic diseasesSemantic proximity Read

A proteome-wide association study of cardiovascular diseases in 640,000 participants of multiple ancestriesSemantic proximity Read

Genomic evaluation of circulating proteins for drug target characterisation and precision medicineSemantic proximity Read

Shared proteomic landscape between arteriosclerosis and cardiovascular endpoints: a Mendelian randomization and observational study integrating AlphaFold3 for structural predictionSemantic proximity Read