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Article

scGWAS: landscape of trait-cell type associations by integrating single-cell transcriptomics-wide and genome-wide association studies.

Genome biology - 17 Oct 2022

Jia Peilin, Hu Ruifeng, Yan Fangfang, Dai Yulin, Zhao Zhongming

Abstract excerpt

BACKGROUND: The rapid accumulation of single-cell RNA sequencing (scRNA-seq) data presents unique opportunities to decode the genetically mediated cell-type specificity in complex diseases. Here, we develop a new method, scGWAS, which effectively leverages scRNA-seq data to achieve two goals: (1) to infer the cell types in which the disease-associated genes manifest and (2) to construct cellular modules which...

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Identifiers

PMID: 36253801
DOI: 10.1186/s13059-022-02785-w
PMCID: PMC9575201

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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