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Article

EPIC: Inferring relevant cell types for complex traits by integrating genome-wide association studies and single-cell RNA sequencing.

PLoS genetics - 1 Jun 2022

Wang Rujin, Lin Dan-Yu, Jiang Yuchao

Abstract excerpt

More than a decade of genome-wide association studies (GWASs) have identified genetic risk variants that are significantly associated with complex traits. Emerging evidence suggests that the function of trait-associated variants likely acts in a tissue- or cell-type-specific fashion. Yet, it remains challenging to prioritize trait-relevant tissues or cell types to elucidate disease etiology. Here, we present EPIC...

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PMID: 35709291
DOI: 10.1371/journal.pgen.1010251
PMCID: PMC9242467

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