Article

scEPS integrates genetic and single-cell disease atlas data to provide granular mechanistic insights into complex human diseases

2026-06-30

Abstract excerpt

Integrating GWAS and single-cell data holds great potential for prioritizing causal disease biology at cellular resolution. Recent integrative approaches typically assess the enrichment of disease genetic signals in cell types or individual cells, without directly modeling disease phenotypes. We develop a new method, single-cell Expression exPlainability Statistics (scEPS), for identifying disease-associated cell...

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Literature Corpus work: 4bda4716-a054-5a4d-b22c-9d3741b11e0c
DOI: 10.64898/2026.06.26.26356714

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