Article

Single-cell based integrative analysis of transcriptomics and genetics reveals robust associations and complexities for inflammatory diseases

2024-06-20

Abstract excerpt

<h4>Background</h4> Understanding genetic underpinnings of immune-mediated inflammatory diseases is crucial to improve treatments. Single-cell RNA sequencing (scRNA-seq) identifies cell states expanded in disease, but often overlooks genetic causality due to cost and small genotyping cohorts. Conversely, large genome-wide association studies (GWAS) are commonly accessible. <h4>Methods</h4> We present a 3-step ro...

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Literature Corpus work: dc7d9228-1518-584d-8ff9-96313aa4c0a3
DOI: 10.1101/2024.06.17.599349

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