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Article

Predicting Mutations Generated by Cas9, Base Editing, and Prime Editing in Mammalian Cells.

The CRISPR journal - 1 Aug 2023

Weller Juliane, Pallaseni Ananth, Koeppel Jonas, Parts Leopold

Abstract excerpt

The first fruits of the CRISPR-Cas revolution are starting to enter the clinic, with gene editing therapies offering solutions to previously incurable genetic diseases. The success of such applications hinges on control over the mutations that are generated, which are known to vary depending on the targeted locus. In this review, we present the current state of understanding and predicting CRISPR-Cas cutting,...

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PMID: 37339457
DOI: 10.1089/crispr.2023.0016

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