Article

Signatures in CRISPR Mutational Spectra Reveal Role and Interplay of Genes in DNA Repair

2025-11-26

Abstract excerpt

<h4>Motivation</h4> Understanding double-strand break (DSB) repair and its disruption is key to decipher genomic instability driving diseases such as cancer and reveal therapeutic avenues. Numerous genes have been linked to DSB repair for the first time in recent genome-wide perturbation studies assessing effects on mutational outcomes. However, the functional roles of most such genes remain poorly understood. Ev...

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Literature Corpus work: 539ec9db-fb0f-5add-a989-c7f895dbed98
DOI: 10.1101/2025.11.25.690381

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