Article

A genetic model for <i>in vivo</i> proximity labeling of the mammalian secretome

2022-04-15

Abstract excerpt

Organ functions are highly specialized and interdependent. Secreted factors regulate organ development and mediate homeostasis through serum trafficking and inter-organ communication. Enzyme-catalyzed proximity labeling enables the identification of proteins within a specific cellular compartment. Here, we report a BirA*G3 mouse strain that enables CRE-dependent promiscuous biotinylation of proteins trafficking t...

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Literature Corpus work: 0c6b7f17-dc04-5630-b7ff-ef923b2c88dd
DOI: 10.1101/2022.04.13.488228

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