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The secretome mouse provides a genetic platform to delineate tissue-specific in vivo secretion

11 Jan 2021

Abstract excerpt

At present, it remains difficult to deconvolute serum in order to identify the cell or tissue origin of a given circulating protein. Here, by exploiting the properties of proximity biotinylation, we describe a mouse model that enables the elucidation of the in vivo tissue-specific secretome. As an example, we demonstrate how we can readily identify in vivo endothelial-specific secretion as well as how this model...

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PMID: 33431665
DOI: 10.1073/pnas.2005134118

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