Article

ProteasomeID: quantitative mapping of proteasome interactomes and substrates for <i>in vitro</i> and <i>in vivo</i> studies

2022-08-09

Abstract excerpt

<h4>SUMMARY</h4> Proteasomes are essential molecular machines responsible for the degradation of proteins in eukaryotic cells. Altered proteasome activity has been linked to neurodegeneration, auto-immune disorders and cancer. Despite the relevance for human disease and drug development, no method currently exists to monitor proteasome composition and interactions in vivo in animal models. To fill this gap, we d...

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Literature Corpus work: c553244f-8a2d-53fb-8650-a756318849c2
DOI: 10.1101/2022.08.09.503299

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