Article

Defining the cardiac fibroblast secretome in the healthy and infarcted mouse heart

2024-08-08

Abstract excerpt

Cardiac fibroblasts (CF) are key players after myocardial infarction (MI), but their signaling is only incompletely understood. Here we report a first secretome atlas of CF in control (cCF) and post-MI hearts (miCF), combining a rapid cell isolation technique with SILAC and click chemistry. In CF, numerous paracrine factors involved in immune homeostasis were identified. Comparing secretome, transcriptome (SLAMseq...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 914f3200-bef6-5e8f-b881-1cf5e16fbd97
DOI: 10.1101/2024.08.06.606146

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Defining the cardiac fibroblast secretome in the healthy and infarcted mouse heartDOI 10.1101/2024.08.06.606146Read

Integration mapping of cardiac fibroblast single-cell transcriptomes elucidates cellular principles of fibrosis in diverse pathologiesSemantic proximity Read

Targeting the Immune-Fibrosis Axis in Myocardial Infarction and Heart FailureSemantic proximity Read

Single-cell expression profiling reveals dynamic flux of cardiac stromal, vascular and immune cells in health and injurySemantic proximity Read

Fibroblast polarization over the myocardial infarction time continuum shifts roles from inflammation to angiogenesisSemantic proximity Read

Macrophage and fibroblast trajectory inference and crosstalk analysis during myocardial infarction using integrated single-cell transcriptomic datasetsSemantic proximity Read

Dynamic molecular atlas of cardiac fibrosis at single-cell resolution shows CD248 in cardiac fibroblasts orchestrates interactions with immune cellsSemantic proximity Read

Cardiac Fibroblast DiversitySemantic proximity Read

Transcriptome and proteome profiling of activated cardiac fibroblasts supports target prioritization in cardiac fibrosisSemantic proximity Read

The Role of Cardiac Fibroblast Heterogeneity in Myocardial Fibrosis and Its Novel Therapeutic PotentialSemantic proximity Read

Single cell study of cellular diversity and mutual communication in chronic heart failure and drug repositioningSemantic proximity Read

Dysferlin is a novel regulator of COMP-positive matrifibrocytes in heart failureSemantic proximity Read

Deciphering Cell-Type-Specific Gene Expression Signatures of Cardiac Diseases Through Reconstruction of Bulk TranscriptomesSemantic proximity Read