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Article

Protease-controlled secretion and display of intercellular signals.

Nature communications - 17 Feb 2022

Vlahos Alexander E, Kang Jeewoo, Aldrete Carlos A, Zhu Ronghui, Chong Lucy S, Elowitz Michael B, Gao Xiaojing J

Abstract excerpt

To program intercellular communication for biomedicine, it is crucial to regulate the secretion and surface display of signaling proteins. If such regulations are at the protein level, there are additional advantages, including compact delivery and direct interactions with endogenous signaling pathways. Here we create a modular, generalizable design called Retained Endoplasmic Cleavable Secretion (RELEASE), with...

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Identifiers

PMID: 35177637
DOI: 10.1038/s41467-022-28623-y
PMCID: PMC8854555

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